Meta-analysis of non-occupational physical activity and cardiovascular disease, cancer and mortality outcomes
Ali Abbas
May 5, 2023
Structure
Agenda
Meta-Analysis
Physical Activity (PA) and its relationship with diseases/mortality
Outcomes of interest
Interactive Interface
Code to access the dose-response curves
Meta-Analysis
What is meta-analysis?
Statistical technique for combining data from multiple studies on a particular topic.
Synthesizing evidence and summarizing the results of individual studies
The Evidence-Based Medicine Pyramid
Meta-analysis of diseases and PA
Cardiovascular diseases cause 17.9 million deaths per year in 2019
Cancers are responsible for 9.6 million deaths in 2017
Physical Activity is known to reduce the risk of cardiovascular diseases, cancers and early deaths
Physical Activity
The shape of the dose-response curves has not been established for a range of chronic diseases (Garcia et al. (2023))
Key finding: 1 in 10 premature deaths can be avoided if everyone achieves 75 minutes of vigorous-intensity activity a week
Higher level of PA is associated with lower risk of all outcomes
Eligibility Criteria
Prospective cohort studies with general population samples of greater than 10K adults
3 or more physical activity categories
Risk measures and Confidence Interval (CIs) for host of measures/disease end points
Studies
196 studies
94 cohorts
> 30 Million participants
Interactive Interface
Outcomes - overall
Outcomes - Level 1
Outcomes - Level 2
Outcomes - Level 3
Outcome category and type
Meta-analysis and dose-range
Dose distribution and Potential Impact Fraction (PIF)
Code
R Package
An R package called dose-response physical activity (drpa) is created
It is open source and hosted on GitHub
You may need to install it used remotes::install_github("meta-analyses/drpa")
# Specify the cause, outcome_type and the doserr <- drpa::dose_response(cause = cause_name, outcome_type = outcome_type, dose = float)
Code Animations
An R package called dose-response physical activity is created
It is open source and hosted on GitHub . . .
Arguments
Arguments for the dose_response function
Garcia, Leandro, Matthew Pearce, Ali Abbas, Alexander Mok, Tessa Strain, Sara Ali, Alessio Crippa, et al. 2023. “Non-Occupational Physical Activity and Risk of Cardiovascular Disease, Cancer and Mortality Outcomes: A Dose–Response Meta-Analysis of Large Prospective Studies.”British Journal of Sports Medicine.